Wednesday, November 21, 2007

Are Scientists Playing God? It Depends on Your Religio

reposted from: http://richarddawkins.net/article,1895,n,n

by John Tierney, NY Times

Thanks to Richard Prins for the link.

Reposted from:
http://www.nytimes.com/2007/11/20/science/20tier.html

Now that biologists in Oregon have reported using cloning to produce a monkey embryo and extract stem cells, it looks more plausible than before that a human embryo will be cloned and that, some day, a cloned human will be born. But not necessarily on this side of the Pacific.


baby globe
American and European researchers have made most of the progress so far in biotechnology. Yet they still face one very large obstacle — God, as defined by some Western religions.


While critics on the right and the left fret about the morality of stem-cell research and genetic engineering, prominent Western scientists have been going to Asia, like the geneticists Nancy Jenkins and Neal Copeland, who left the National Cancer Institute and moved last year to Singapore.

Asia offers researchers new labs, fewer restrictions and a different view of divinity and the afterlife. In South Korea, when Hwang Woo Suk reported creating human embryonic stem cells through cloning, he did not apologize for offending religious taboos. He justified cloning by citing his Buddhist belief in recycling life through reincarnation.

When Dr. Hwang's claim was exposed as a fraud, his research was supported by the head of South Korea's largest Buddhist order, the Rev. Ji Kwan. The monk said research with embryos was in accord with Buddha's precepts and urged Korean scientists not to be guided by Western ethics.

"Asian religions worry less than Western religions that biotechnology is about 'playing God,'" says Cynthia Fox, the author of "Cell of Cells," a book about the global race among stem-cell researchers. "Therapeutic cloning in particular jibes well with the Buddhist and Hindu ideas of reincarnation."

You can see this East-West divide in maps drawn up by Lee M. Silver, a molecular biologist at Princeton. Dr. Silver, who analyzes clashes of spirituality and science in his book "Challenging Nature," has been charting biotechnology policies around the world and trying to make spiritual sense of who's afraid of what.

Most of southern and eastern Asia displays relatively little opposition to either cloned embryonic stem-cell research or genetically modified crops. China, India, Singapore and other countries have enacted laws supporting embryo cloning for medical research (sometimes called therapeutic cloning, as opposed to reproductive cloning intended to recreate an entire human being). Genetically modified crops are grown in China, India and elsewhere.


hearts
In Europe, though, genetically modified crops are taboo. Cloning human embryos for research has been legally supported in England and several other countries, but it is banned in more than a dozen others, including France and Germany.

In North and South America, genetically altered crops are widely used. But embryo cloning for research has been banned in most countries, including Brazil, Canada and Mexico. It has not been banned nationally in the United States, but the research is ineligible for federal financing, and some states have outlawed it.

Dr. Silver explains these patterns by dividing spiritual believers into three broad categories. The first, traditional Christians, predominate in the Western Hemisphere and some European countries. The second, which he calls post-Christians, are concentrated in other European countries and parts of North America, especially along the coasts. The third group are followers of Eastern religions.
"Most people in Hindu and Buddhist countries," Dr. Silver says, "have a root tradition in which there is no single creator God. Instead, there may be no gods or many gods, and there is no master plan for the universe. Instead, spirits are eternal and individual virtue — karma — determines what happens to your spirit in your next life. With some exceptions, this view generally allows the acceptance of both embryo research to support life and genetically modified crops."

By contrast, in the Judeo-Christian tradition, God is the master creator who gives out new souls to each individual human being and gives humans "dominion" over soul-less plants and animals. To traditional Christians who consider an embryo to be a human being with a soul, it is wrong for scientists to use cloning to create human embryos or to destroy embryos in the course of research.

But there is no such taboo against humans' applying cloning and genetic engineering to "lower" animals and plants. As a result, Dr. Silver says, cloned animals and genetically modified crops have not become a source of major controversy for traditional Christians. Post-Christians are more worried about the flora and fauna.
"Many Europeans, as well as leftists in America," Dr. Silver says, "have rejected the traditional Christian God and replaced it with a post-Christian goddess of Mother Nature and a modified Christian eschatology. It isn't a coherent belief system. It might or might not incorporate New Age thinking. But deep down, there's a view that humans shouldn't be tampering with the natural world." Hence the opposition to genetically modified food.

Because post-Christians do not necessarily share the biblical view of an omnipotent deity with the sole power to create souls, Dr. Silver says, they are less worried about scientists "playing God" in the laboratory with embryos. In places like California, residents have voted not only to allow embryo cloning for research, but also to finance it.


But sometimes the reverence for the natural world extends to embryos, leading to unlikely alliances. When conservative intellectuals like Francis Fukyama campaigned for Congress to ban embryo cloning, some environmental activists like Jeremy Rifkin joined them. A Green Party leader in Germany, Voker Beck, referred to cloned embryonic stem-cell research as "veiled cannibalism."

Of course, many critics of biotechnology do not explicitly use religious dogma to justify their opposition. Countries like the United States, after all, are supposed to be guided by secular constitutions, not sectarian creeds. So opponents of genetically modified foods focus on the possible dangers to ecosystems and human health, and committees of scientists try to resolve the debate by conducting risk analysis.

The outcome hinges more on beliefs than on scientific data. A study finding that genetically modified foods are safe might reassure traditional Christians in Kansas, but it won't stop post-Christians in Stockholm from worrying about "Frankenfood."

Similarly, some leading opponents of embryo research for cloning, like Leon Kass, say they are defending not Judeo-Christian beliefs, but "human dignity." Dr. Kass, former chairman of the President's Council on Bioethics, says the special status of humans described in the Book of Genesis should be heeded not because of the Bible's authority, but because the message reflects a "cosmological truth."

It is not so easy, though, to defend supposedly self-evident truths about human nature that are not evident to a large portion of humanity. Conservatives in the House of Representatives managed to pass a bill banning Americans from going overseas for stem-cell treatments derived through embryo cloning. But the bill didn't pass the Senate.

It is by no means certain that this type of stem-cell research will ever yield treatments for diseases like Parkinson's, but should that happen, it is hard to see how any Congress — or any law — could stop people from seeking cures.

The prospect of cloning children is much more distant, particularly now that researchers are becoming optimistic about obtaining stem cells without using embryos. For now, scientists throughout the world say they do not even want to contemplate reproductive cloning because of the risks to the child. And public-opinion polls do not show much support for it anywhere.

Even if human cloning becomes safe, there may never be much demand for it, because most people will prefer having children the old-fashioned way.

But some people may desperately want a cloned child — perhaps to replace one who died or to provide lifesaving bone marrow for a sibling — and won't be dissuaded, no matter how many Christians or post-Christians try to stop them. To reach this frontier, they may just go east.

Tuesday, November 20, 2007

The Best Reason Yet to Support Stem Cell Research

reposted from: ragingdonkey.com

The Best Reason Yet to Support Stem Cell Research by Hans Phingers 6/24/2004 10:55 PM


The Best Reason Yet to Support Stem Cell Research by Hans Phingers

ARTIST’S COMMENTS: Can any of us honestly say we haven’t dreamed of having tiny hands on the ends of our fingers and thumbs? Well, evolution may have fallen asleep at the wheel, but stem cell research could very well make finger-hands a possibility! Or at least that’s what my total lack of familiarity with virtually all scientific disciplines has led me to believe. But never mind that - let’s, for now, just think about the incredible advantage finger-hands would give us. Now, my numbers may be a bit off here, but I think it’s reasonable to assume that with finger-hands we would all be able to type somewhere in the neighbourhood of 12 000 words per minute, and although almost no one would be able to afford manicures anymore, sign language would be the high speed communication tool of the future, we could all give massages to beat the band, and everyone in the world would be a piano player extraordinaire! Also, even a small group of people would be able to create tremendous levels of applause, thereby bringing huge amounts of joy to street performers everywhere. So, in conclusion, stem cell research will almost certainly lead us to a utopian civilization made possible by the incredible versatility of finger-hands.

'This is a very exciting advance'

reposted from: http://news.bbc.co.uk/1/hi/health/7103787.stm

'This is a very exciting advance'
By Dr Lyle Armstrong
Geneticist

Fibroblast
Fibroblast skin cells were transformed by the new technology
Scientists have discovered a way to reprogramme human skin cells so that they mimic embryonic stems with the potential to become any tissue in the body.

The breakthrough promises to have signficant implications for medical research.

Scientists are very excited by the announcement of these findings, that cells that look and act like stem cells can be created from skin cells (known in science as fibroblasts).

Last year similar work was done in mice, and we were waiting with bated breath to see if it would also work in humans.

Embryonic stem cells have great potential for treating human disease because of their ability to generate almost all the cell types found in the adult body.

These stem cells are important to study many diseases, but in the future they may also be used to as a treatment in their own right.

There is potential that stem cells could help replace diseased, damaged or dying cells and contribute towards improved function of that person's organs, possibly representing a cure for the disease from which they suffered.

If there is any hope of getting to this stage, researchers have a major hurdle to get over - preventing the immune system rejecting the new cells.

The best way to prevent this is to match the stem cells to the person - in the same way as doctors match organs in transplant operations.

So researchers are looking for ways to make stem cell lines to match individual patients.

Patient specific cells

Scientists have been hoping that therapeutic cloning would hold the key to creating patient specific stem cells.

In therapeutic cloning the DNA of one of the patient¿s cells is transferred into a human (or animal) egg from which the DNA had been removed, this is tricked into dividing into an embryo that scientists extract stem cells from.

However, therapeutic cloning uses human eggs which are not readily available and the procedure is technically difficult.

Additionally, there are people who have ethical concerns about the use of embryos to create stem cells.

For all of these reasons, this research gives us some hope of finding an alternative source of embryonic stem cells.

It is important that this breakthrough should not prevent work on therapeutic cloning.

But rather we should seek to embrace both techniques.

We do not clearly understand the mechanism by which new technique works and further research is needed.

  • Dr Armstrong is based at the North East England Stem Cell Institute, International Centre For Life, University of Newcastle.
  • Skin transformed into stem cells

    reposted from: http://news.bbc.co.uk/1/hi/health/7101834.stm
    RELATED INTERNET LINKS
    Comment on Reproductive Ethics

    Skin transformed into stem cells
    Cell created by Japanese team
    Pluripotent cell created by Japanese researchers
    Human skin cells have been reprogrammed by two groups of scientists to mimic embryonic stem cells with the potential to become any tissue in the body.

    The breakthrough promises a plentiful new source of cells for use in research into new treatments for many diseases.

    Crucially, it could mean that such research is no longer dependent on using cells from human embryos, which has proved highly controversial.

    The US and Japanese studies feature in the journals Science and Cell.

    The induced cells do all the things embryonic stem cells do - its going to completely change the field
    Professor James Thomson
    University of Wisconsin-Madison

    Until now only cells taken from embryos were thought to have an unlimited capacity to become any of the 220 types of cell in the human body - a so-called pluripotent state.

    But campaigners have objected to their use on the grounds that it is unethical to destroy embryos in the name of science.

    In the US only limited use of embryonic stem cells is allowed by scientists receiving public funding.

    The Japanese team used a chemical cocktail containing just four gene-controlling proteins to transform adult human fibroblasts - skin cells that are easy to obtain and grow in culture - into a pluripotent state.

    For once we have better science coinciding with better ethics
    Josephine Quintavalle
    Comment on Reproductive Ethics

    The cells created were similar, but not identical, to embryonic stem cells, and the researchers used them to produce brain and heart tissue.

    After 12 days in the laboratory clumps of cells grown to mimic heart muscle tissue started beating.

    The US team, from the University of Wisconsin-Madison, achieved the same effect by using a slightly different combination of chemicals.

    They have created eight new stem cell lines for potential use in research.

    Cloning superceded

    Using skin cells should mean that treatments could be personalised for individual patients, minimising the risk of rejection.

    Although it is early days for this technique it may well prove to be every bit as significant as the first derivation of human embryonic stem cells nine years ago
    Dr Lyle Armstrong
    University of Newcastle Upon Tyne

    Not only does the new technique remove the need to create embryos in the lab, it is also more simple, and more precisely controlled than current cloning technology.

    Professor Ian Wilmut, of the University of Edinburgh, who led the team which created Dolly the sheep in 1996, has said it represents a significant advance.

    However, the researchers have warned more work is needed to refine the process, and ensure its safety.

    At present both techniques rely on viruses to introduce new material into the cells, which carries a potential risk.

    Researcher Professor James Thomson said: "The induced cells do all the things embryonic stem cells do.

    "It's going to completely change the field."

    Dr Shinya Yamanaka, of Kyoto University, a member of the Japanese research team, said: "These cells should be extremely useful in understanding disease mechanisms and screening effective and safe drugs."

    Positive reaction

    Professor Azim Surani, of the University of Cambridge, said the research should allow scientists to create a large range of human stem cell types, which could prove invaluable in studying disease.

    He said: "It is relatively easy to grow an entire plant from a small cutting, something that seems inconceivable in humans.

    "Yet this study brings us tantalisingly close to using skin cells to grow many different types of human tissues.

    Dr Lyle Armstrong, of the International Centre For Life at the University of Newcastle Upon Tyne, called the studies a "major development".

    He said: "Although it is early days for this technique it may well prove to be every bit as significant as the first derivation of human embryonic stem cells nine years ago."

    Professor Robin Lovell-Badge, of the Medical Research Council's National Institute For Medical Research, said the work was exciting, but work was required to end the reliance on viruses, and to tease out why two different techniques produced similar results.

    Josephine Quintavalle, of Comment on Reproductive Ethics, said: "News that embryonic stem cells can be created successfully from human cells without cloning, without using human embryos or human eggs, or without getting involved in the creation of animal-human embryos, is most warmly welcomed.

    "We congratulate these world-class scientists who have had the courage to state their change of tack so cogently.

    "For once we have better science coinciding with better ethics."

    TECHNIQUES FOR MAKING 'STEM CELLS'
    graphic showing different techniques for stem cell creation
    Therapeutic cloning produces stem cells which can develop into different types of body cell, making them ideal for research into treatment of disease.
    But this technology involves the creation and destruction of embryos, which is ethically controversial. The stem cells created also run the risk of being rejected by the body.
    The new technology, nuclear reprogramming, creates stem-like cells from the patient's own cells, avoiding both these problems.


    Monday, November 19, 2007

    world's first cloned embryos from an adult monkey

    reposted from: http://news.bbc.co.uk/player/nol/newsid_7090000/newsid_7095500/7095554.stm?bw=bb&mp=wm&asb=1&news=1

    Scientists have successfully created the world's first cloned embryos from an adult monkey.

    Thursday, November 1, 2007

    Apathy halts Nobel winner's talk

    reposted from: http://news.bbc.co.uk/1/hi/wales/south_east/7036435.stm

    Apathy halts Nobel winner's talk
    Sir Martin Evans
    Professor Sir Martin Evans was knighted in 2003
    A day after he was awarded the Nobel Prize, a talk on stem cell research by Sir Martin Evans has been cancelled because of a "lack of interest".

    The event, due to be held at Cardiff's Techniquest, was organised before he was awarded the 2007 Nobel Prize for medicine on Monday.

    The Biotechnology and Biological Sciences Research Council had arranged the event six weeks ago.

    It will now be re-scheduled for sometime in the new year.

    The public discussion on Wednesday was to feature Sir Martin and Dr Nick Allen, both from Cardiff University.

    A similar discussion went ahead at Tehniquest in October 2006 involving the same people.

    Sir Martin, a professor of mammalian genetics, is considered by many the chief architect of stem cell research.

    Alter genes

    He was knighted in 2003 and received the Lasker award - the American equivalent of the Nobel Prize for medicine - in 2001.

    He is also a fellow of the Royal Society and fellow of the Academy of Medical Sciences.

    The 66-year-old scientist helped show how the cells that form all the tissues in a mouse's body - embryonic stem cells - can be removed and grown separately in the lab.

    He also helped create a method to alter genes in mice.

    Dr Christine Hauskeller from the University of Exeter was also expected to talk about the ethical and societal issues that stem cell science raises.

    The meeting was to be chaired by Dr Anita Shaw, Development Director of Techniquest.